Curcumin Plus
Curcumin Plus features BCM-95®—a 100% pure turmeric extract standardized to curcumin, demethoxycurcumin, bisdemethoxycurcumin, and essential oils of turmeric rhizome. This natural composition optimizes bioavailability and reflects true turmeric identity to deliver optimal health benefits. BCM-95 has been extensively studied and shows broad efficacy without the use of phospholipids, excipients, additives, carriers, nanotechnology, or bioenhancers.*
Immune Support and Antioxidant Activity
Research has demonstrated that curcumin has antioxidant activity, is an immune cell modulator, and has inhibitory effects on COX-2, iNOS enzymes, TNF-α, IL, and NF-ĸB, making it applicable to a wide array of clinical presentations. Various animal and human studies support its use in promoting health in joints, gastrointestinal mucosa, and the eye’s uveal tract. Other research suggests curcumin may support balanced immune response in the nervous, cardiovascular, GI, and respiratory systems. Neurological tissue is particularly susceptible to oxidative stress due to its high demand for oxygen, high levels of polyunsaturated fatty acids in neural membrane phospholipids, and low antioxidant defenses.[10] Exciting new research in the field of brain and neurological health points to the protective effects of curcumin. Interest in curcumin in this regard is related to its oxidant/immune modulating activity and positive effect on brain amyloid plaques. Typical doses in human studies ranged from 375 mg -1,200 mg curcumin per day.*
Cell-Protective
In animal models, curcumin has demonstrated desirable activity in promoting normal cell proliferation in many, but not all, cell lines. Mechanisms appear to include curcumin’s ability to modulate certain types of cytokines (especially transcription factor NF-ĸB), support detoxification, scavenge free radicals, and to support induction of cell cycle arrest and apoptosis. Animal studies, and Phase I and Phase II clinical trials are encouraging; more clinical trials are needed and underway. Typical doses in human studies ranged from 450 mg – 3,600 mg curcumin per day for up to four months.*
Healthy Microbial Environment
Curcumin has long been used to support a healthy microbial balance; this historical use has been supported by more recent in vitro studies.*